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Article

Dose response study for 1,3-butadiene-induced dominant lethal mutations and heritable translocations in germs cells of male mice.

Mutation research - 16 Jan 1998

Adler I D, Filser J, Gonda H, Schriever-Schwemmer G

Abstract excerpt

Butadiene (BD) and its metabolites have extensively been studied in the EU sponsored research project "Multi-endpoint analysis of genetic damage induced by 1,3-butadiene and its major metabolites". Within this project a dominant lethal test and a heritable translocation test were performed with male mice to study the dose-response relationships for the respective endpoints. BD concentrations of 130 and 500 ppm...

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PMID: 9463555
DOI: 10.1016/s0027-5107(97)00198-x

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