Article
Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene.
Chemico-biological interactions - 20 Mar 2007
Meng Quanxin, Walker Dale M, McDonald Jake D, Henderson Rogene F, Carter Meghan M, Cook Dennis L, McCash Consuelo L, Torres Salina M, Bauer Michael J, Seilkop Steven K, Upton Patricia B, Georgieva Nadia I, Boysen Gunnar, Swenberg James A, Walker Vernon E
Abstract excerpt
Experiments were performed: (i) to investigate potential age- and gender-dependent differences in mutagenic responses in T cells following exposures of B6C3F1 mice and F344 rats by inhalation for 2 weeks to 0 or 1250 ppm butadiene (BD), and (ii) to determine if exposures for 2 weeks to 62.5 ppm BD produce a mutagenic effect in female rats. To evaluate the effect of age on mutagenic response, mutant manifestation...
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