Article
Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity.
Nature - 1 Jan 2000
Marshall H, Nonchev S, Sham M H, Muchamore I, Lumsden A, Krumlauf R
Abstract excerpt
It has been suggested that Hox genes play an important part in the patterning of limbs, vertebrae and craniofacial structures by providing an ordered molecular system of positional values, termed the Hox code. Little is known about the nature of the signals that govern the establishment and regulation of Hox genes, but retinoic acid can affect the expression of these genes in cell lines and in embryonic tissues....
Topics
- Animals
- Axons
- Branchial Region
- Cell Movement
- DNA-Binding Proteins
- Early Growth Response Protein 2
- Facial Bones
- Gene Expression
- Genes, Homeobox
- Mice
- Mice, Inbred CBA