Article
Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.
Development (Cambridge, England) - 1 Aug 2001
Gavalas A, Trainor P, Ariza-McNaughton L, Krumlauf R
Abstract excerpt
Hoxa1 and Hoxb1 have overlapping synergistic roles in patterning the hindbrain and cranial neural crest cells. The combination of an ectoderm-specific regulatory mutation in the Hoxb1 locus and the Hoxa1 mutant genetic background results in an ectoderm-specific double mutation, leaving the other germ layers impaired only in Hoxa1 function. This has allowed us to examine neural crest and arch patterning defects...
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