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Article

Evidence of Independent Origin of Multiple Tumors From Patients With Prostate Cancer

4 Feb 1998

Abstract excerpt

BACKGROUND: In men with prostate cancer, the gland usually contains two or more widely separate tumors. A critical issue of prostatic carcinogenesis is whether these multiple tumors are independent in origin. Molecular analysis of microsatellite (i.e., highly repeated, short nucleotide sequences) alterations in the DNA from separate tumors in the same prostate can be used to determine whether or not these...

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Identifiers

PMID: 9462681
DOI: 10.1093/jnci/90.3.233

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