Article
Combination of tumor necrosis factor alpha and interferon alpha induces apoptotic cell death through a c-myc-dependent pathway in p53 mutant H226br non-small-cell lung cancer cell line.
Experimental cell research - 10 Dec 2001
Yasuoka Y, Naomoto Y, Yamatsuji T, Takaoka M, Kimura M, Uetsuka H, Matsubara N, Fujiwara T, Gunduz M, Tanaka N, Haisa M
Abstract excerpt
We investigated the role of wild-type p53 and c-myc activity in apoptosis induced by a combination of natural human tumor necrosis factor alpha (TNF-alpha) and natural human interferon alpha (IFN-alpha). Studies were performed with two human non-small-cell lung cancer cell lines, H226b, which has wild-type p53, and H226br, which has a mutant p53. The combination of IFN-alpha and TNF-alpha significantly inhibited...
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