Article
Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.
Developmental cell - 1 Apr 2008
Centanin Lázaro, Dekanty Andrés, Romero Nuria, Irisarri Maximiliano, Gorr Thomas A, Wappner Pablo
Abstract excerpt
Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we show that extra sprouting depends on the Hypoxia-Inducible Factor (HIF)-alpha homolog Sima and on...
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