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Article

[Value of p53 immunohistochemistry in diagnosing esophageal squamous intraepithelial neoplasia].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 8 Jul 2026

Jing H Y, Meng Z Y, Zhou W X

Abstract excerpt

食管鳞状上皮内瘤变（ESIN）是食管鳞状细胞癌（ESCC）的癌前病变，早期发现并及时干预具有重要的临床意义。TP53基因突变被认为是ESCC发生的早期关键事件。p53免疫组织化学（IHC）可在蛋白水平反映TP53异常，已广泛用于辅助诊断。但因其判读标准不一且易受炎症等因素干扰，p53 IHC在ESIN诊断中的应用仍存争议。本文综述p53生物学基础与典型IHC表达模式，归纳国内外判读要点与进展，评估p53 IHC在ESIN诊断及分级中的价值。探讨与TP53测序、多标志物联合及数字病理的整合应用，以提升ESIN诊断的客观性与准确性。.

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Share to Carcinoma, Squamous Cell
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Identifiers

PMID: 42379859
DOI: 10.3760/cma.j.cn112151-20260427-00297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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