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Article

Attenuation of Japanese encephalitis virus by selection of its mouse brain membrane receptor preparation escape variants.

Virology - 1 Feb 1998

Ni H, Barrett A D

Abstract excerpt

Six variants of Japanese encephalitis (JE) virus strain P3 were selected for resistance to binding to mouse brain membrane receptor preparations (MRP). All but one of these MRP escape (MRPR) variants were significantly attenuated in mice for both neuroinvasiveness (>200-fold) and neurovirulence (>500-fold) compared to their parent virus. Attenuated mouse brain MRPR variants could be detected in the sera of mice...

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Identifiers

PMID: 9454714
DOI: 10.1006/viro.1997.8956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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