Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic changes in the Japanese encephalitis virus after one passage in Neuro-2a cells: generation of attenuated strains of the virus.

Vaccine - 21 Dec 2007

Chiou Shyan-Song, Chen Wei-June

Abstract excerpt

Live attenuated strains of the Japanese encephalitis (JE) virus are known to form in various cultured cells. In this study, we selected attenuated JE virus variants by passing the parent virus strains once through Neuro-2a cells, showing that the selection intensity ranged 2-1000-fold after infection for 3d. The selection of attenuated variants appeared in association with mutations on the envelope (E)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Encephalitis Virus, Japanese
Share to Heparin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred ICR

Share to Neuroblastoma

Share to Vaccines, Attenuated

Share to Vero Cells

Share to Virulence

Source

Identifiers

PMID: 18045754
DOI: 10.1016/j.vaccine.2007.10.047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic changes in the Japanese encephalitis virus after one passage in Neuro-2a cells: generation of attenuated strains of the virus.PMID 18045754Read ↗

Fitness of Japanese encephalitis virus to Neuro‐2a cells is determined by interactions of the viral envelope protein with highly sulfated glycosaminoglycans on the cell surfaceSemantic proximity Read ↗

Phenotypic and genotypic characterization of the neurovirulence and neuroinvasiveness of a large-plaque attenuated Japanese encephalitis virus isolate.Semantic proximity Read ↗

Phenotypic and genotypic characteristics of Japanese encephalitis attenuated live vaccine virus SA14-14-2 and their stabilities.Semantic proximity Read ↗

Characterization of live-attenuated Japanese encephalitis vaccine virus SA14-14-2.Semantic proximity Read ↗

A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice.Semantic proximity Read ↗

Adaptation of a live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes.Semantic proximity Read ↗

Comparison of the live-attenuated Japanese encephalitis vaccine SA14 -14-2 strain with its pre-attenuated virulent parent SA14 strain: similarities and differences in vitro and in vivoSemantic proximity Read ↗

Enhanced cytopathic effect of Japanese encephalitis virus strain SA14-14-2: Probable association of mutation in amino acid of its envelope protein.Semantic proximity Read ↗

Genetic and phenotypic properties of vero cell-adapted Japanese encephalitis virus SA14-14-2 vaccine strain variants and a recombinant clone, which demonstrates attenuation and immunogenicity in mice.Semantic proximity Read ↗

Identification of mutations that occurred on the genome of Japanese encephalitis virus during the attenuation process.Semantic proximity Read ↗

[Study on the phenotypic characteristics of Japanese encephalitis virus strains isolated from different years].Semantic proximity Read ↗

Envelope Protein Mutations L107F and E138K Are Important for Neurovirulence Attenuation for Japanese Encephalitis Virus SA14-14-2 StrainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.