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Molecular differences between wild-type Japanese encephalitis virus strains of high and low mouse neuroinvasiveness

1 Jul 1996

Abstract excerpt

Japanese encephalitis (JE) virus strain P3 was highly neurovirulent and neuroinvasive in weanling mice whereas two other JE virus strains, SA14/USA and S892, were only neurovirulent. Infectivity titrations of brains and sera showed that P3 virus multiplied faster and reached a higher infectivity titre than S892 virus following inoculation of viruses by the intraperitoneal (i.p.) route. The p.f.u./LD50 was 10(1.7)...

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PMID: 8757986
DOI: 10.1099/0022-1317-77-7-1449

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