Article
Mutations in the envelope protein of Japanese encephalitis virus affect entry into cultured cells and virulence in mice.
Virology - 1 Nov 1992
Hasegawa H, Yoshida M, Shiosaka T, Fujita S, Kobayashi Y
Abstract excerpt
The nucleotide sequences of the envelope protein of the Kamiyama 1 strain of Japanese encephalitis (JE) virus and a passaged mutant (Kamiyama 2 strain) were determined. Two amino acid differences, Ser-Phe at residue 364 and Asn-Ile at residue 367, distinguished Kamiyama 2 from Kamiyama 1. Six neutralization-resistant variants were selected from these two strains using a JE species-specific monoclonal antibody...
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