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A highly attenuated rabies virus HEP-Flury strain reverts to virulent by single amino acid substitution to arginine at position 333 in glycoprotein.

Virus research - 1 Aug 2006

Takayama-Ito Mutsuyo, Inoue Ken-Ichi, Shoji Yoko, Inoue Satoshi, Iijima Toshio, Sakai Takeo, Kurane Ichiro, Morimoto Kinjiro

Abstract excerpt

An amino acid at position 333 in the glycoprotein of several fixed rabies virus strains is responsible for the pathogenicity in adult mice. Substitution of arginine at this position largely reduces the viral pathogenicity in adult mice. Attenuation by this single amino acid substitution has been established by using escape mutants selected by monoclonal antibodies and point-mutated virus generated by...

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PMID: 16473429
DOI: 10.1016/j.virusres.2006.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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