Article
Pick's disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system.
Acta neuropathologica - 1 Jan 1998
Hayashi S, Wakabayashi K, Iwanaga K, Kakita A, Seki K, Tanaka M, Okuizumi K, Onodera O, Tanaka H, Tsuji S, Takahashi H
Abstract excerpt
We carried out immunohistochemical examination of apolipoprotein E (apoE) in brains from two patients with Pick's disease. In these cases 1 and 2, the APOE genotypes were epsilon 3/4 and epsilon 3/3, respectively. In both cases, numerous argyrophilic globular intraneuronal inclusions, Pick bodies (PBs), were distributed widely throughout the brain, and immunohistochemically were occasionally positive for apoE....
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