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Article

Mechanism of Translation Termination: RF1 Dissociation Follows Dissociation of RF3 from the Ribosome.

Biochemistry - 15 Nov 2016

Shi Xinying, Joseph Simpson

Abstract excerpt

Release factors 1 and 2 (RF1 and RF2, respectively) bind to ribosomes that have a stop codon in the A site and catalyze the release of the newly synthesized protein. Following peptide release, the dissociation of RF1 and RF2 from the ribosome is accelerated by release factor 3 (RF3). The mechanism for RF3-promoted dissociation of RF1 and RF2 is unclear. It was previously proposed that RF3 hydrolyzes GTP and...

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Identifiers

PMID: 27779391
DOI: 10.1021/acs.biochem.6b00921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of Translation Termination: RF1 Dissociation Follows Dissociation of RF3 from the Ribosome.PMID 27779391Read ↗

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