Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry.

doi:10.1128/JVI.71.9.6509-6516.1997

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Article

Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry.

Journal of virology - 1 Sept 1997

Kirchhoff F, Pöhlmann S, Hamacher M, Means R E, Kraus T, Uberla K, Di Marzio P

Abstract excerpt

The recent identification of coreceptors that mediate efficient entry of human immunodeficiency virus type 1 (HIV-1) suggests new therapeutic and preventive strategies. We analyzed simian immunodeficiency virus (SIV) entry cofactors to investigate whether the macaque SIV model can be used as an e...

Topics

Animals
Biological Factors
Cell Line
Genetic Variation
HIV Envelope Protein gp120
Humans
Macrophages, Alveolar
Membrane Fusion
Membrane Glycoproteins
Proline
Receptors, CCR5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cytokine

Receptors, HIV

Serine

Simian Immunodeficiency Virus

T-Lymphocytes

Viral Envelope Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 9261370
DOI: 10.1128/JVI.71.9.6509-6516.1997
PMCID: PMC191926

Genes

CCR5
CCR1
CCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9261370-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry.PMID 9261370Read ↗

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