Drug extrusion in Corynebacterium glutamicum.

doi:10.1089/mdr.1997.3.345

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Article

Drug extrusion in Corynebacterium glutamicum.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1997

Kaidoh K, Kimura M, Miyauchi S, Nara T, Kamo N

Abstract excerpt

We selected a mutant of Corynebacterium glutamicum, EBR, which can grow in a medium containing cytotoxic ethidium bromide (EtBr) at a high concentration of 100 microM. The resistance to EtBr in the mutant was reversed by 2 microM reserpine, a potent inhibitor of mammalian p-glycoprotein and bacte...

Topics

Adenosine Triphosphate
Anti-Bacterial Agents
Corynebacterium
Drug Resistance, Microbial
Drug Resistance, Multiple
Ethidium
Genes, MDR
Membrane Potentials
Microbial Sensitivity Tests
Mutation
Reserpine

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