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Article

Involvement of an efflux system in mediating high level of fluoroquinolone resistance in Mycobacterium smegmatis.

Biochemical and biophysical research communications - 13 Sept 1996

Banerjee S K, Bhatt K, Rana S, Misra P, Chakraborti P K

Abstract excerpt

A wild type strain of Mycobacterium smegmatis mc2 155 was serially adapted to 64 fold of minimal inhibitory concentration of an antimycobacterial agent, ciprofloxacin. This clone (CIPr) exhibited cross resistance to ofloxacin and ethidium bromide. The rate of drug efflux was accelerated in CIPr compared to the wild type strain. Verapamil, a calcium channel blocker, enhanced the drug accumulation in CIPr by...

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Identifiers

PMID: 8806641
DOI: 10.1006/bbrc.1996.1362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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