Article
The human Rh50 glycoprotein gene. Structural organization and associated splicing defect resulting in Rh(null) disease.
The Journal of biological chemistry - 23 Jan 1998
Huang C H
Abstract excerpt
The Rh (Rhesus) protein family comprises Rh50 glycoprotein and Rh30 polypeptides, which form a complex essential for Rh antigen expression and erythrocyte membrane integrity. This article describes the structural organization of Rh50 gene and identification of its associated splicing defect causing Rhnull disease. The Rh50 gene, which maps at chromosome 6p11-21.1, has an exon/intron structure nearly identical to...
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