Article
Compound heterozygosity of two novel RHAG alleles leads to a considerable disruption of the Rh complex.
Transfusion - 1 Apr 2016
Polin Helene, Pelc-Klopotowska Monika, Danzer Martin, Suessner Susanne, Gabriel Christian, Wilflingseder Julia, Żmudzin Alicja, Orzińska Agnieszka, Guz Katarzyna, Michalewska Bogumila, Brojer Ewa
Abstract excerpt
BACKGROUND: The Rhesus (Rh) complex consists of a core comprising the Rh proteins (RhD/RhCE) and the Rh-associated glycoprotein (RhAG) with accessory chains (GPB, LW, CD47). Molecular defects of the RHAG gene may cause a regulator Rhnull phenotype without Rh antigen expression or a Rhmod phenotype with decreased Rh antigen expression. STUDY DESIGN AND METHODS: Blood samples of a donor with strongly diminished Rh...
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