A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type.

Article

A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type.

Blood - 15 Feb 1998

Hyland C A, Chérif-Zahar B, Cowley N, Raynal V, Parkes J, Saul A, Cartron J P

Abstract excerpt

Rare individuals who lack all of the Rh blood group antigens are called Rhnull and may be classified as "regulator" or "amorph" types. The suppression of Rh antigen expression for regulator types may be attributed to mutations of the RH50 gene, which is independent of the RH locus. The RH50 gene...

Topics

Blood Donors
Blood Proteins
Female
Glycoproteins
Heterozygote
Humans
Male
Membrane Glycoproteins
Mutation
Rh-Hr Blood-Group System

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.