Article
Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency.
Nature genetics - 1 Feb 1996
Cherif-Zahar B, Raynal V, Gane P, Mattei M G, Bailly P, Gibbs B, Colin Y, Cartron J P
Abstract excerpt
The Rh antigen is a multi-subunit complex composed of Rh polypeptides and associated glycoproteins (Rh50, CD47, LW and glycophorin B); these interact in the red cell membrane and are lacking or severely reduced in Rhnull cells. As a result, individuals with Rhnull suffer chronic haemolytic anaemi...
Topics
- Amino Acid Sequence
- Anemia, Hemolytic
- Antigens, CD
- Base Sequence
- Blood Proteins
- CD47 Antigen
- Carrier Proteins
- Chromosome Mapping
- DNA Mutational Analysis
- Erythrocyte Membrane
- Female
- Genes, Suppressor
- Glycoproteins
- Humans
- Male
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation