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Article

Ablation of Egr2-positive cells in male mouse anterior pituitary leads to atypical isolated GH deficiency.

Endocrinology - 1 Jan 2013

Bouchoucha Yassine Xavier, Charnay Patrick, Gilardi-Hebenstreit Pascale

Abstract excerpt

In this study, we have investigated the expression and function of the transcription factor early growth response factor 2 (Egr2)/Krox20 in the developing anterior pituitary. Egr2 is initially expressed in all differentiating hormonal cells types, but its expression is mostly restricted to the somatotroph lineage after birth. Egr2 knockout results in anterior pituitary hypoplasia. However, the analysis of a...

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PMID: 23150495
DOI: 10.1210/en.2012-1792

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