Article
Genetic analysis of de novo CD5+ diffuse large B-cell lymphomas suggests an origin from a somatically mutated CD5+ progenitor B cell.
Blood - 15 Jan 2003
Katzenberger Tiemo, Lohr Andreas, Schwarz Stephan, Dreyling Martin, Schoof Julia, Nickenig Christina, Stilgenbauer Stephan, Kalla Jörg, Ott M Michaela, Müller-Hermelink Hans Konrad, Ott German
Abstract excerpt
CD5(+) diffuse large B-cell lymphomas (DLBLs) have recently been described as a particular subgroup of DLBLs. Classical banding and interphase cytogenetic analyses targeting ATM, TP53, and P16(INK4a) genes and the D13S25 locus from 13 CD5(+) DLBLs were compared with 55 CD5(-) DLBLs. Additionally, analysis of somatic mutations of the immunoglobulin heavy chain variable region (IgVH) genes were performed in CD5(+)...
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