Article
Molecular biology of colorectal cancer: new targets.
Seminars in oncology - 1 Dec 2006
Kitisin Krit, Mishra Lopa
Abstract excerpt
Colorectal cancer is an ideal model in which to study malignant progression from the molecular-genetic perspective because different stages of the same malignancy coexist within each patient. Approximately 75% of colorectal cancer cases are sporadic and the remaining are familial disease, yet genetic mutations that have been identified account for only 5% to 6% of inherited cases. The two major pathways by which...
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