Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis.

doi:10.1002/(SICI)1520-6823(1997)5:6<265::AID-ROI1>3.0.CO;2-W

Article

Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis.

Radiation oncology investigations - 1 Jan 1997

Jung M, Zhang Y, Dritschilo A

Abstract excerpt

Ataxia telangiectasia (AT) cells exhibit greater levels of apoptosis than normal fibroblasts following exposure to X-rays or radiomimetic drugs. In this study, we investigated apoptosis in AT cells whose radiation sensitivity has been altered by transfection with a cDNA expressing truncated I kappa B-alpha (delta I kappa B-alpha). delta I kappa B-alpha functions as a dominant negative regulatory protein of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis.

Abstract excerpt

Topics

Related research