Article
The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data.
Genetic epidemiology - 1 Jan 1997
Siegmund K D, Todorov A A, Rao D C, Borecki I B
Abstract excerpt
We compare the results of genomic scans conducted with the Haseman-Elston sib-pair method using either (1) the average marker information from several adjacent loci or (2) each marker individually. Under smoothing, the squared sib-pair trait difference is regressed on the average number of allele...
Topics
- Alleles
- Chromosomes, Human, Pair 8
- Data Interpretation, Statistical
- Genetic Linkage
- Genetic Markers
- Genetic Testing
- Genome, Human
- Humans
- Matched-Pair Analysis
- Nuclear Family
- Predictive Value of Tests
- Quantitative Trait, Heritable
- Regression Analysis
- Statistics, Nonparametric