Article
The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data.
Genetic epidemiology - 1 Jan 1997
Siegmund K D, Todorov A A, Rao D C, Borecki I B
Abstract excerpt
We compare the results of genomic scans conducted with the Haseman-Elston sib-pair method using either (1) the average marker information from several adjacent loci or (2) each marker individually. Under smoothing, the squared sib-pair trait difference is regressed on the average number of alleles shared identical by descent averaged at several adjacent loci. This results in a significant decrease in the number...
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