Haplotype sharing analysis in affected individuals from nuclear families with at least one affected offspring.

doi:10.1002/(SICI)1098-2272(1997)14:6<915::AID-GEPI59>3.0.CO;2-P

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Article

Haplotype sharing analysis in affected individuals from nuclear families with at least one affected offspring.

Genetic epidemiology - 1 Jan 1997

Van der Meulen M A, te Meerman G J

Abstract excerpt

In diseases with a complex mode of inheritance, families with multiple affected individuals are difficult to ascertain. The haplotype sharing statistic (HSS) uses (hidden) co-ancestry between affected individuals from a founder population. These affected individuals will likely not only share the...

Topics

Chromosome Mapping
Female
Genetic Diseases, Inborn
Genome, Human
Haplotypes
Humans
Logistic Models
Male
Mutation
Nuclear Family
Predictive Value of Tests

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