Article
Most parsimonious haplotype allele sharing determination.
BMC bioinformatics - 21 Apr 2009
Cai Zhipeng, Sabaa Hadi, Wang Yining, Goebel Randy, Wang Zhiquan, Xu Jiaofen, Stothard Paul, Lin Guohui
Abstract excerpt
BACKGROUND: The "common disease--common variant" hypothesis and genome-wide association studies have achieved numerous successes in the last three years, particularly in genetic mapping in human diseases. Nevertheless, the power of the association study methods are still low, in particular on quantitative traits, and the description of the full allelic spectrum is deemed still far from reach. Given increasing...
Topics
- Alleles
- Chromosome Mapping
- Computer Simulation
- Genome, Human
- Genome-Wide Association Study
- Genotype
- Haplotypes
- Humans
- Pedigree
- Polymorphism, Single Nucleotide