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Article

Interdonor variability of platelet response to thrombin receptor activation: influence of PlA2 polymorphism.

British journal of haematology - 1 Dec 1997

Lasne D, Krenn M, Pingault V, Arnaud E, Fiessinger J N, Aiach M, Rendu F

Abstract excerpt

Considering that platelet response to thrombin receptor activation might be critical for the development of arterial thrombosis, we measured the dense granule release under stimulation by the thrombin receptor activating peptide (TRAP) in a series of 102 healthy volunteers. The threshold TRAP concentration which initiated a secretion ranged from 3 to 20 microM. A good concordance (79%, k=0.677) between two tests...

Topics

Blood Platelets
Genotype
Humans
Peptide Fragments
Plasminogen Activator Inhibitor 2
Platelet Glycoprotein GPIIb-IIIa Complex
Polymorphism, Genetic
Receptors, Thrombin

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9432025
DOI: 10.1046/j.1365-2141.1997.4973300.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9432025-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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