Article
Variability of platelet indices and function: acquired and genetic factors.
Handbook of experimental pharmacology - 1 Jan 2012
de Gaetano Giovanni, Santimone Iolanda, Gianfagna Francesco, Iacoviello Licia, Cerletti Chiara
Abstract excerpt
Each individual has an inherent variable risk of bleeding linked to genetic or acquired abnormal platelet number or platelet dysfunction. In contrast, it is less obvious that the variability of platelet phenotypes (number, mean platelet volume, function) may contribute to the variable individual risk of thrombosis. Interindividual variability of platelet indices or function may be either due to acquired factors,...
Topics
- Aspirin
- Blood Platelets
- Cell Size
- Clopidogrel
- Genome-Wide Association Study
- Humans
- Platelet Count
- Polymorphism, Single Nucleotide
- Ticlopidine