Article
Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel.
Blood - 13 Dec 2012
Dawood Ban B, Lowe Gillian C, Lordkipanidzé Marie, Bem Danai, Daly Martina E, Makris Mike, Mumford Andrew, Wilde Jonathan T, Watson Steve P
Abstract excerpt
Light transmission aggregometry (LTA) is used worldwide for the investigation of heritable platelet function disorders (PFDs), but interpretation of results is complicated by the feedback effects of ADP and thromboxane A(2) (TxA(2)) and by the overlap with the response of healthy volunteers. Over 5 years, we have performed lumi-aggregometry on 9 platelet agonists in 111 unrelated research participants with...
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