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Article

Isolation and characterization of two mutants of human profilin I that do not bind poly(L-proline).

FEBS letters - 1 Dec 1997

Björkegren-Sjögren C, Korenbaum E, Nordberg P, Lindberg U, Karlsson R

Abstract excerpt

A simple procedure for the isolation of profilin mutants having a reduced capacity to bind poly(L-proline) is used to isolate two mutants of human profilin I, W3N and H133S. Binding of the mutants to poly(L-proline), actin, and phosphatidylinositol (4,5)-bisphosphate (PIP2) was studied. Both mutations abolished the poly(L-proline)-binding activity of profilin. This suggests that the arrangement of the N- and...

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PMID: 9428724
DOI: 10.1016/s0014-5793(97)01376-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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