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Article

EDEN and EDEN-BP, a cis element and an associated factor that mediate sequence-specific mRNA deadenylation in Xenopus embryos.

The EMBO journal - 2 Jan 1998

Paillard L, Omilli F, Legagneux V, Bassez T, Maniey D, Osborne H B

Abstract excerpt

During Xenopus early development, gene expression is regulated mainly at the translational level by the length of the poly(A) tail of mRNAs. The Eg family and c-mos maternal mRNAs are deadenylated rapidly and translationally repressed after fertilization. Here, we characterize a short sequence element (EDEN) responsible for the rapid deadenylation of Eg5 mRNA. Determining the core EDEN sequence permitted us to...

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Identifiers

PMID: 9427761
DOI: 10.1093/emboj/17.1.278
PMCID: PMC1170378

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