Article

Andexanet alfa-associated heparin resistance in cardiac surgery: mechanism and <i>in vitro</i> perspectives

2024-09-10

Abstract excerpt

<h4>Background</h4> Andexanet alfa (andexanet) is the only FDA-approved antidote for direct factor Xa (FXa) inhibitors but has been reported to cause resistance to unfractionated heparin (UFH). This has delayed anticoagulation for procedures requiring cardiopulmonary bypass (CPB). The mechanism, andexanet and UFH dose dependence, and thrombotic risk of andexanet-associated heparin resistance are unknown. <h4>Meth...

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Literature Corpus work: 403adbc6-9c26-5bae-97e1-725a5a90e3d5
DOI: 10.1101/2024.09.09.612152

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