Article
4-Aminobiphenyl-DNA adducts and p53 mutations in bladder cancer.
International journal of cancer - 9 Feb 1998
Martone T, Airoldi L, Magagnotti C, Coda R, Randone D, Malaveille C, Avanzi G, Merletti F, Hautefeuille A, Vineis P
Abstract excerpt
Epidemiologic studies have suggested that smokers of air-cured tobacco (rich in arylamines) are at higher risk of bladder cancer than smokers of flue-cured tobacco. The risk has been shown to be modulated by the N-acetyltransferase genotype. We analyzed the biopsies of 45 patients with bladder ca...
Topics
- Adult
- Aged
- Aminobiphenyl Compounds
- Arylamine N-Acetyltransferase
- DNA Adducts
- Genes, p53
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Mutation
- Plants, Toxic
- Smoking
- Nicotiana
- Urinary Bladder Neoplasms