Article
Screening for p53 gene mutations in archived tumors of workers occupationally exposed to carcinogens: examples from analysis of bladder tumors.
Journal of occupational and environmental medicine - 1 Jan 1995
Esteve A, Sørlie T, Martel-Planche G, Hollstein M, Kusters I, Lewalter J, Vineis P, Stephan-Odenthal M, Montesano R
Abstract excerpt
Point mutations in the p53 tumor suppressor gene are the most common genetic alterations in human cancers. The nature and location of these mutations can be informative in assessing the importance of putative carcinogenic agents. Potential associations between a given carcinogen and a specific mu...
Topics
- Base Sequence
- Carcinogens
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Occupational Exposure
- Polymerase Chain Reaction
- Risk Factors
- Urinary Bladder Neoplasms