Article
Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 1997
Rothman N, Talaska G, Hayes R B, Bhatnagar V K, Bell D A, Lakshmi V M, Kashyap S K, Dosemeci M, Kashyap R, Hsu F F, Jaeger M, Hirvonen A, Parikh D J, Davis B B, Zenser T V
Abstract excerpt
We evaluated the influence of urine pH on the proportion of urinary benzidine (BZ) and N-acetylbenzidine present in the free, unconjugated state and on exfoliated urothelial cell DNA adduct levels in 32 workers exposed to BZ in India. Postworkshift urine pH was inversely correlated with the proportions of BZ (r = -0.78; P < 0.0001) and N-acetylbenzidine (r = -0.67; P < 0.0001) present as free compounds....
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