Article
Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.
Genomics - 1 Dec 1997
Reddy P H, Stockburger E, Gillevet P, Tagle D A
Abstract excerpt
The expansion of a (CAG)n trinucleotide repeat has been associated with at least eight neurological disorders in which the repeats code for polyglutamine in the protein. To identify additional genes that possess (CAG)n repeats, single-stranded cDNA clones derived from adult human brain were scree...
Topics
- Adult
- Blotting, Northern
- Brain
- Chromosome Mapping
- Genetic Techniques
- Genetic Variation
- Humans
- In Situ Hybridization
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid
- Sequence Analysis, DNA
- Sequence Homology, Nucleic Acid
- Sequence Tagged Sites
- Streptavidin
- Tissue Distribution
- Transcription, Genetic
- Trinucleotide Repeats