Article
Identification of CAG repeat-containing genes expressed in human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases.
Journal of human genetics - 1 Jan 2002
Tachikawa Masaji, Nagai Yoshitaka, Nakamura Koichiro, Kobayashi Kazuhiro, Fujiwara Tsutomu, Han Hye-Jung, Nakabayashi Yuko, Ichikawa Yaeko, Goto Jun, Kanazawa Ichiro, Nakamura Yusuke, Toda Tatsushi
Abstract excerpt
To obtain novel candidate genes for autosomal dominant spinocerebellar ataxia and other neurodegenerative disorders in which gene mutations remain unidentified, we screened a human fetal brain cDNA library using (CAG)(10) repeat probes. Sixteen cDNAs were isolated and mapped to chromosomes 1, 2, 3, 6, 9, 13, 15, 16, 22, and X. Although we failed to detect abnormal CAG repeat expansion within these genes in...
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