Article
CAG/CTG and CGG/GCC repeats in human brain reference cDNAs: outcome in searching for new dynamic mutations.
Genomics - 1 Feb 1998
Albanese V, Holbert S, Saada C, Meier-Ewert S, Lebre A S, Moriniere S, Bougueleret L, Le Gall I, Weissenbach J, Lennon G, Lehrach H, Cohen D, Cann H M, Neri C
Abstract excerpt
CAG and CGG expansion is associated with 10 inherited neurological diseases and is thought to be involved in other human genetic diseases. To identify new candidate genes, we have undertaken a large-scale screening project for CAG/CTG ([CAG]n) and CGG/GCC ([CGG]n) repeats in human brain reference...
Topics
- Brain
- Chromosome Walking
- DNA, Complementary
- Fetus
- Gene Frequency
- Gene Library
- Genetic Testing
- Genome, Human
- Humans
- Infant
- Mutation
- Nucleic Acid Hybridization
- Trinucleotide Repeats