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Article

Markerless modification of trinucleotide repeat loci in BACs.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Benzow Kellie A, Koob Michael D

Abstract excerpt

Transcription and splicing of human genes are regulated by nucleotide sequences encoded across large segments of our genome, and trinucleotide repeat expansion mutations can have both profound and subtle effects on these processes. In the course of our work to understand the impact of the Spinocerebellar Ataxia type 8 (SCA8) CTG repeat expansion on the transcription and splicing of the RNAs encoded near the SCA8...

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PMID: 23754231
DOI: 10.1007/978-1-62703-411-1_17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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