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Article

Allele-selective suppression of mutant genes in polyglutamine diseases.

Journal of neurogenetics - 1 Jan 2015

Liu Chia-Rung, Cheng Tzu-Hao

Abstract excerpt

Polyglutamine (polyQ) diseases are heritable dominant neurological disorders, caused by abnormal CAG tri-nucleotide expansion in the coding sequence of affected genes. Extension of CAG repeats results in the production of aberrant gene products that are deleterious to neurons, such as transcripts with a CAG stem-loop secondary structure, and proteins containing a long stretch of polyQ residues. Thus, determining...

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PMID: 26174158
DOI: 10.3109/01677063.2015.1073275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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