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Article

Identification of Potential Modifiers of Runx2/Cbfa1 Activity in C2C12 Cells in Response to Bone Morphogenetic Protein-7

1 Jan 2004

Abstract excerpt

Treatment with BMP-7 causes a shift in the differentiation pathway from myoblastic to osteoblastic in C2C12 mouse myoblast precursor cells in vitro. The underlying molecular mechanism is largely unknown. BMP-7 at 200 ng/ml completely inhibited myotube formation in C2C12 cells and dramatically induced alkaline phosphatase activity up to 20-fold when compared to untreated cells by day 12 in culture. The level of...

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PMID: 14745233
DOI: 10.1159/000075025

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Source receipt: pubmed, retrieved 7 Sept 2026.

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