Article
Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation.
Journal of cellular biochemistry - 1 Apr 1999
Lee M H, Javed A, Kim H J, Shin H I, Gutierrez S, Choi J Y, Rosen V, Stein J L, van Wijnen A J, Stein G S, Lian J B, Ryoo H M
Abstract excerpt
The bone morphogenetic protein (BMP)-2 is a potent osteoinductive signal, inducing bone formation in vivo and osteoblast differentiation from non-osseous cells in vitro. The runt domain-related protein Cbfa1/PEBP2alphaA/AML-3 is a critical component of bone formation in vivo and transcriptional regulator of osteoblast differentiation. To investigate the relationship between the extracellular BMP-2 signal, Cbfa1,...
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