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Article

Histone‐specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double‐stranded DNA antibody production

1 Dec 1997

Abstract excerpt

OBJECTIVE: To investigate whether histone-specific T helper (Th) cells that are able to induce anti-double-stranded DNA (anti-dsDNA) antibodies can be isolated from patients with systemic lupus erythematosus (SLE) and to characterize the cytokine secretion pattern of such Th clones. METHODS: Peripheral blood mononuclear cells from SLE patients and healthy donors were stimulated with autologous apoptotic cell...

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PMID: 9416853
DOI: 10.1002/art.1780401210

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