Article
Haplotype analysis of two recurrent CDKN2A mutations in 10 melanoma families: evidence for common founders and independent mutations.
Human mutation - 1 Jan 1998
Pollock P M, Spurr N, Bishop T, Newton-Bishop J, Gruis N, van der Velden P A, Goldstein A M, Tucker M A, Foulkes W D, Barnhill R, Haber D, Fountain J, Hayward N K
Abstract excerpt
Germ-line mutations in CDKN2A have been shown to predispose to cutaneous malignant melanoma. We have identified 2 new melanoma kindreds which carry a duplication of a 24bp repeat present in the 5' region of CDKN2A previously identified in melanoma families from Australia and the United States. This mutation has now been reported in 5 melanoma families from 3 continents: Europe, North America, and Australasia. The...
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