Article
Genetic analysis by peptide nucleic acid affinity MALDI-TOF mass spectrometry.
Nature biotechnology - 1 Dec 1997
Griffin T J, Tang W, Smith L M
Abstract excerpt
The ability to analyze multiple polymorphic sites rapidly and accurately is crucial in all areas of genetic analysis. We have developed an approach for the detection of multiple point mutations, using allele-specific, mass-labeled, peptide nucleic acid (PNA) hybridization probes, and direct analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The composite mass spectra...
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