Article
Matrix-assisted laser desorption/ionization mass spectrometric analysis of DNA on microarrays.
Clinical chemistry - 1 Jul 2006
Kepper Pamela, Reinhardt Richard, Dahl Andreas, Lehrach Hans, Sauer Sascha
Abstract excerpt
BACKGROUND: Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is a powerful tool in biomolecule analysis with a wide range of application possibilities, including genotyping of single-base variations (also known as single-nucleotide polymorphisms, or SNPs) for candidate gene studies and diagnostic typing of DNA markers. We tested a method that does not require stringent purification of the...
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