Article
Relationship between duration of rheumatoid arthritis before knee joint surgery and HLA-DRB1 alleles: a retrospective study.
The Journal of rheumatology - 1 Dec 1997
Toda Y, Takemura S, Komuro H, Ono H, Tanabe T, Nakagawa T, Morimoto T, Ogawa R
Abstract excerpt
OBJECTIVE: To examine whether genetically determined factors can be used as predictors of requirement for knee joint surgery in the early phase of rheumatoid arthritis (RA). METHODS: We determined HLA-DRB1 alleles in 322 patients with seropositive RA by polymerase chain reaction and allele specific oligonucleotide probe techniques. Patients were classified into 3 groups (S/S, S/N, and N/N) based on their...
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